Methyl Methacrylate → Verapamil

HRID 1408273

반응식

HRID 1408273 반응식
[CH3:1][CH:2]([C:4]([C:24]1[CH:25]=[CH:26][C:27]([O:32][CH3:33])=[C:28]([O:30][CH3:31])[CH:29]=1)([C:22]#[N:23])[CH2:5][CH2:6][CH2:7][N:8]([CH2:10][CH2:11][C:12]1[CH:13]=[CH:14][C:15]([O:20][CH3:21])=[C:16]([O:18][CH3:19])[CH:17]=1)[CH3:9])[CH3:3].Cl.CC(C(OC)=O)=C>>[CH3:3][CH:2]([C:4]([C:24]1[CH:25]=[CH:26][C:27]([O:32][CH3:33])=[C:28]([O:30][CH3:31])[CH:29]=1)([C:22]#[N:23])[CH2:5][CH2:6][CH2:7][N:8]([CH2:10][CH2:11][C:12]1[CH:13]=[CH:14][C:15]([O:20][CH3:21])=[C:16]([O:18][CH3:19])[CH:17]=1)[CH3:9])[CH3:1]

참가 물질

3

반응물 2

HCID 6658Methyl MethacrylateHCID 62969Verapamil Hydrochloride

생성물 1

HCID 2520Verapamil

실험 절차

Weighed quantities of verapamil hydrochloride and Eudragit L100 were mixed in a blender. The mass was granulated using molten compritol. Granules of verapamil thus obtained were further blended using Kollidon SR and lactose, lubricated using magnesium stearate and compressed into tablets.

후처리

  1. additionwere mixed in a blender

출처 및 근거

ORD 기록
ord-d47fd98b27b4490fbc9b58a92169d264
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08920837B2

연결된 노트

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