Hydrochloric Acid → HCID 58897002, 화합물

HRID 1409120노트

반응식

HRID 1409120 반응식
[C:1]1([CH3:27])[CH:6]=[CH:5][C:4]([S:7]([N:10]2[C:14]3=[N:15][CH:16]=[CH:17][C:18]([C:19]4[CH:20]=[C:21]([CH2:25]O)[CH:22]=[CH:23][CH:24]=4)=[C:13]3[CH:12]=[CH:11]2)(=[O:9])=[O:8])=[CH:3][CH:2]=1.[Li+].[OH-].[ClH:30]>C1COCC1.O>[Cl:30][CH2:25][C:21]1[CH:20]=[C:19]([C:18]2[CH:17]=[CH:16][N:15]=[C:14]3[N:10]([S:7]([C:4]4[CH:5]=[CH:6][C:1]([CH3:27])=[CH:2][CH:3]=4)(=[O:9])=[O:8])[CH:11]=[CH:12][C:13]=23)[CH:24]=[CH:23][CH:22]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 58896939HCID 58896939, 화합물

생성물 1

HCID 58897002HCID 58897002, 화합물

시약·촉매·용매 2

HCID 962Water용매2회HCID 8028Tetrahydrofuran용매

실험 절차

To a stirred solution of compound G″ in THF, water was added LiOH (3.68 g, 0.087 mol) at rt and stirred for 4 h at same temperature. The reaction mixture was concentrated to obtain residue which was diluted with water (50 ml), acidified with 2N aq. HCl solution, adjusted to pH=5-6, the precipitated solid was filtered, washed with water and dried (traces water were removed by co-evaporating with toluene) to obtain compound H″. The compound H″ was washed with diethyl ether to obtain desired purity.

후처리

  1. concentrationThe reaction mixture was concentrated
  2. customto obtain residue which
  3. filtrationthe precipitated solid was filtered
  4. washwashed with water
  5. customdried
  6. custom(traces water were removed by co-evaporating with toluene)

출처 및 근거

ORD 기록
ord-b511e69037344932a42fc6664733c342
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08921376B2

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