Hydrochloric Acid → HCID 71093738, 화합물

HRID 1409711노트

반응식

HRID 1409711 반응식
C[O:2][C:3]([C:5]1(OC)[O:9][N:8]=[C:7]([C:10]2[CH:15]=[CH:14][C:13]([C:16]#[N:17])=[CH:12][C:11]=2[F:18])[CH2:6]1)=[O:4].[OH-].[Na+].Cl>O1CCCC1>[C:16]([C:13]1[CH:14]=[CH:15][C:10]([C:7]2[CH:6]=[C:5]([C:3]([OH:4])=[O:2])[O:9][N:8]=2)=[C:11]([F:18])[CH:12]=1)#[N:17]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 866861563-(4-Cyano-2-fluoro-phenyl)-5-methoxy-4,5-dihydro-isoxazole-5-carboxylic acid methyl ester

생성물 1

HCID 71093738HCID 71093738, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 3-(4-cyano-2-fluoro-phenyl)-5-methoxy-4,5-dihydro-isoxazole-5-carboxylic acid methyl ester (172 mg), 1N aqueous NaOH solution (2 mL), and tetrahydrofuran (5 mL) is stirred at room temperature for 3 h. The reaction mixture is acidified with 1 N hydrochloric acid (approximately pH 3) and concentrated in vacuo. The residue is triturated with water and the precipitate is filtered off and dried to give the title compound. LC (method 18): tR=0.38 min; Mass spectrum (ESI−): m/z=231 [M−H]−.

후처리

  1. concentrationconcentrated in vacuo
  2. customThe residue is triturated with water
  3. filtrationthe precipitate is filtered off
  4. customdried

출처 및 근거

ORD 기록
ord-2edb0fb4e3dd43f7aed6105505f3c49a
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08921398B2

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