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Hydrochloric Acid → 5-(4-Methoxyphenyl)-2-(thiophen-2-yl)oxazole-4-carboxylic acid

HRID 1410458
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반응식

HRID 1410458 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:13][C:12]([C:14]3[S:15][CH:16]=[CH:17][CH:18]=3)=[N:11][C:10]=2[C:19]([O:21]CC)=[O:20])=[CH:5][CH:4]=1.[OH-].[Li+].Cl>CO.C(Cl)Cl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:13][C:12]([C:14]3[S:15][CH:16]=[CH:17][CH:18]=3)=[N:11][C:10]=2[C:19]([OH:21])=[O:20])=[CH:5][CH:4]=1
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참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 68518280Ethyl 5-(4-methoxyphenyl)-2-(thiophen-2-yl)oxazole-4-carboxylate

생성물 1

HCID 292814635-(4-Methoxyphenyl)-2-(thiophen-2-yl)oxazole-4-carboxylic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 6344Dichloromethane
용매

반응 조건

온도
50 °C

실험 절차

To a solution of ethyl 5-(4-methoxyphenyl)-2-(thiophen-2-yl)oxazole-4-carboxylate in MeOH (2 mL) and DCM (0.5 mL) was added 1M aqueous lithium hydroxide solution (2 mL, 2 mmol). The reaction mixture was stirred at 50° C. overnight and then 2M aqueous HCl (0.125 mL) was added and the solvent removed in vacuo to afford 5-(4-methoxyphenyl)-2-(thiophen-2-yl)oxazole-4-carboxylic acid which was used without further purification. LCMS (1) Rt: 1.34 min; m/z (ES+) 302.

후처리

  1. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-58d74665780a4a56802babd27d324917
출처 데이터셋
uspto-grants-2014_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08921544B2

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