Hydrochloric Acid → HCID 21482850, 화합물

HRID 1415559노트

반응식

HRID 1415559 반응식
[CH:1]1([N:7]2[CH2:11][CH2:10][CH:9](O)[CH2:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.S(Cl)([Cl:16])=O.C(=O)([O-])[O-].[Na+].[Na+]>C(Cl)(Cl)Cl>[CH:1]1([N:7]2[CH2:11][CH2:10][CH:9]([Cl:16])[CH2:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 24386Thionyl ChlorideHCID 133874481-Cyclohexylpyrrolidin-3-ol

생성물 1

HCID 21482850HCID 21482850, 화합물

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a stirred solution of 169 g. of N-cyclohexyl-3-pyrrolidinol in 600 ml. of chloroform, acidified with gaseous hydrogen chloride, is added 130 g. of thionyl chloride. This solution is refluxed for four hours, then poured onto ice water and made basic with sodium carbonate. The organic layer is dried over sodium sulfate, concentrated, and the residue distilled in vacuo to give N-cyclohexyl-3-chloropyrrolidine.

후처리

  1. additionis added 130 g
  2. temperatureThis solution is refluxed for four hours
  3. additionpoured onto ice water
  4. dry with materialThe organic layer is dried over sodium sulfate
  5. concentrationconcentrated
  6. distillationthe residue distilled in vacuo

출처 및 근거

ORD 기록
ord-e93ea8fede624f6e8a34b414d514bad6
출처 데이터셋
uspto-grants-1977_01
특허 번호
US04005208

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