Hydrochloric Acid → 2-(Piperidin-3-yl)-1H-isoindole-1,3(2H)-dione

HRID 1415566노트

반응식

HRID 1415566 반응식
NC1CCCNC1.C1(=O)OC(=O)C2=CC=CC=C12.C(C1C=CC=CC=1C([N:26]1[CH2:31][CH2:30][CH2:29][CH:28]([N:32]2[C:36](=[O:37])[C:35]3=[CH:38][CH:39]=[CH:40][CH:41]=[C:34]3[C:33]2=[O:42])[CH2:27]1)=O)(O)=O.Cl>>[C:33]1(=[O:42])[N:32]([CH:28]2[CH2:29][CH2:30][CH2:31][NH:26][CH2:27]2)[C:36](=[O:37])[C:35]2=[CH:38][CH:39]=[CH:40][CH:41]=[C:34]12

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 6811Phthalic AnhydrideHCID 148119Piperidin-3-amineHCID 214828121-(2-Carboxybenzoyl)-3-phthalimidopiperidine

생성물 1

HCID 199722632-(Piperidin-3-yl)-1H-isoindole-1,3(2H)-dione

실험 절차

A mixture of 10 g. of 3-aminopiperidine and 29.6 g. of phthalic anhydride is heated at 150° C. for 30 minutes. This mixture which contains 1-(2-carboxybenzoyl)-3-phthalimidopiperidine is heated at reflux with 500 ml. of 6N hydrochloric acid for two hours. The aqueous phase is extracted with ether and then concentrated in vacuo. The residue is extracted with dilute aqueous sodium hydroxide solution and methylene chloride. The organic phase is dried and concentrated in vacuo to give 3-phthalimidopiperidine.

후처리

  1. additionA mixture of 10 g
  2. temperatureis heated
  3. temperatureat reflux with 500 ml
  4. extractionThe aqueous phase is extracted with ether
  5. concentrationconcentrated in vacuo
  6. extractionThe residue is extracted with dilute aqueous sodium hydroxide solution and methylene chloride
  7. customThe organic phase is dried
  8. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-f8757a0ce6bb4892ae6327e0a4d9eeb0
출처 데이터셋
uspto-grants-1977_01
특허 번호
US04005208

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