M-Cresol → Cresentyl

HRID 1415889노트

반응식

HRID 1415889 반응식
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:10]1[C:15]([OH:16])=[CH:14][CH:13]=[CH:12][C:11]=1[CH3:17].C(N(CC)CC)C>CCOCC>[C:1]([O:16][C:15]1[CH:14]=[CH:13][CH:12]=[C:11]([CH3:17])[CH:10]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 342M-CresolHCID 7412Benzoyl chlorideHCID 8471Triethylamine

생성물 1

HCID 69193Cresentyl수율 212%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

A solution of benzoyl chloride (32.5 g, Aldrich) in ether (200 ml) was added dropwise to a stirred solution of m-cresol (25.0 g, Aldrich) and triethylamine (27.2 g, Aldrich) in ether (500 ml). The reaction mixture was stirred at room temperature for 1 hour then filtered. The ethereal filtrate was washed with saturated NaHCO3 and water then dried over Na2SO4. The ether layer was separated, dried and concentrated in vacuo to give the desired product (104.0 g) as a white solid, mp 45-47C. 1H NMR consistent with the desired structure.

후처리

  1. filtrationthen filtered
  2. washThe ethereal filtrate was washed with saturated NaHCO3 and water
  3. dry with materialthen dried over Na2SO4
  4. customThe ether layer was separated
  5. customdried
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-8232430216cf41ae9ef7c1d6c1f2ebf5
출처 데이터셋
uspto-grants-1999_06
특허 번호
US05910494

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