4-Methylmorpholine → 8-(t-Butoxycarbonyl)amino-octanoic acid methyl-butyl-amide

HRID 1417419노트

반응식

HRID 1417419 반응식
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].CN1CCOCC1.Cl.CN(C)CCCN=C=NCC.Cl.[CH3:39][NH:40][CH2:41][CH2:42][CH2:43][CH3:44].O.OC1C2N=NNC=2C=CC=1>ClCCl.O>[CH3:39][N:40]([CH2:41][CH2:42][CH2:43][CH3:44])[C:16](=[O:18])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][NH:8][C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7]

참가 물질

8

반응물 5

HCID 79724-MethylmorpholineHCID 5462158-(((Tert-butoxy)carbonyl)amino)octanoic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 6337757N-methylbutylamine hydrochlorideHCID 178526939HCID 178526939, 화합물

생성물 1

HCID 537219698-(t-Butoxycarbonyl)amino-octanoic acid methyl-butyl-amide

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매

실험 절차

Combine 8-(t-butoxycarbonyl)amino-octanoic acid (1.28 g, 5 mmol), N-methylmorpholine (1.2 mL, 10 mmol), 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride salt (0.95 g, 5.0 mmol), methyl-butyl amine hydrochloride salt (5.0 mmol), and 4-hydroxybenztriazole hydrate (0.05 g) in dichloromethane (20 mL). After 4 hours, add water and extract with ethyl acetate. Dry the organic layer over MgSO4 and evaporate in vacuo to give the title compound.

후처리

  1. extractionextract with ethyl acetate
  2. dry with materialDry the organic layer over MgSO4
  3. customevaporate in vacuo

출처 및 근거

ORD 기록
ord-d97eb11b1d854ecfac8ea4633b8374a2
출처 데이터셋
uspto-grants-1999_03
특허 번호
US05877202

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