Sodium hydride → 4-[2-[2-Ethyl-4-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl]ethoxy]nitrobenzene

HRID 1419001노트

반응식

HRID 1419001 반응식
[CH2:1]([C:3]1[NH:4][C:5](=[O:10])[CH:6]=[C:7]([CH3:9])[N:8]=1)[CH3:2].Br[CH2:12][CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=1.[Li+].[Br-].[H-].[Na+]>>[CH2:1]([C:3]1[N:4]([CH2:12][CH2:13][O:14][C:15]2[CH:16]=[CH:17][C:18]([N+:21]([O-:23])=[O:22])=[CH:19][CH:20]=2)[C:5](=[O:10])[CH:6]=[C:7]([CH3:9])[N:8]=1)[CH3:2]

참가 물질

5

반응물 4

HCID 24758Sodium hydrideHCID 82050Lithium BromideHCID 2359871-(2-Bromoethoxy)-4-nitrobenzeneHCID 1354173682-Ethyl-6-methylpyrimidin-4(1h)-one

생성물 1

HCID 219601354-[2-[2-Ethyl-4-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl]ethoxy]nitrobenzene수율 30.9%

실험 절차

The title compound (5.2 g, 25%) was prepared from 2-ethyl-4-methyl-1,6-dihydro-6-pyrimidone (7.65 g, 55.43 mmol), 4-[2-bromoethoxy]nitrobenzene (15.0 g, 60.97 mmol), LiBr (11.09 g, 127.49 mmol) and 60% NaH (2.76 g, 72.06 mmol) as base by a similar procedure to that described in preparation 1.

후처리

  1. customthat described in preparation 1

출처 및 근거

ORD 기록
ord-281ffcc29e1f4916b559bc0c2fa71266
출처 데이터셋
uspto-grants-1999_03
특허 번호
US05885997

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