Hydrochloric Acid → 1-(5-Bromo-2-hydroxyphenyl)propan-1-one

HRID 1420752

반응식

HRID 1420752 반응식
C([O:5][C:6]1[CH:11]=[CH:10][C:9]([Br:12])=[CH:8][CH:7]=1)(=O)CC.[Cl-].[Al+3].[Cl-].[Cl-].Cl>>[Br:12][C:9]1[CH:10]=[CH:11][C:6]([OH:5])=[C:7]([C:6](=[O:5])[CH2:7][CH3:8])[CH:8]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 90205p-Bromophenyl propionateHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 7364091-(5-Bromo-2-hydroxyphenyl)propan-1-one수율 191.3%

실험 절차

4-Bromophenyl propionate (115 g) (see Preparation 1) and aluminium chloride (150 g) were heated together at approximately 90° C. for 15 minutes. The solution became dark and hydrogen chloride gas was evolved. After cooling the black mass was carefully added to ice and a brown solid formed. The mixture was extracted with dichloromethane. The organic extract was separated, washed with brine, dried (anhydrous magnesium sulphate) and the solvent removed under reduced pressure to yield 1-(5-bromo-2-hydroxyphenyl)propane-1-one (110 g) as a yellow solid.

후처리

  1. temperatureAfter cooling the black mass
  2. additionwas carefully added to ice
  3. customa brown solid formed
  4. extractionThe mixture was extracted with dichloromethane
  5. extractionThe organic extract
  6. customwas separated
  7. washwashed with brine
  8. dry with materialdried (anhydrous magnesium sulphate)
  9. customthe solvent removed under reduced pressure

출처 및 근거

ORD 기록
ord-b5ee18280d3b4052acecf2454b2c9782
출처 데이터셋
uspto-grants-2000_06
특허 번호
US06071938

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