Benzoyl chloride → 3-(Phenylformamido)butanoic acid
반응식
[NH2:1][CH:2]([CH3:7])[CH2:3][C:4]([OH:6])=[O:5].[C:8](Cl)(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>[OH-].[Na+]>[C:8]([NH:1][CH:2]([CH3:7])[CH2:3][C:4]([OH:6])=[O:5])(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1참가 물질
4
실험 절차
To a cooled solution of 3-aminobutyric acid (13 g) in 2M NaOH (130 ml) is added benzoyl chloride (19.7 g) over the course of two hours. The mixture is allowed to warm to room temperature. Washing with diethyl ether, acidifying the aqueous phase with 20% HCl, extracting with diethyl ether, drying over MgSO4, evaporating the solvent and recrystallizing in either/hexane gives the title compound m.p. 150-152° C. (Compound 1.6, Table 1).
후처리
- washWashing with diethyl ether
- extractionextracting with diethyl ether
- dry with materialdrying over MgSO4
- customevaporating the solvent
- customrecrystallizing in either/hexane
출처 및 근거
- ORD 기록
- ord-455bf8fa641a41c9a857bedaf74b016c
- 출처 데이터셋
- uspto-grants-2000_06
- 특허 번호
- US06075051
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