Hydrochloric Acid → HCID 54239092, 화합물

HRID 1422220노트

반응식

HRID 1422220 반응식
Cl.[NH2:2][CH2:3][C:4]1[CH:13]=[C:12]([Br:14])[CH:11]=[C:10]2[C:5]=1[NH:6][C:7](=[O:16])[C:8](=[O:15])[NH:9]2.[CH2:17]([O:19][C:20](=[O:26])/[CH:21]=[CH:22]/[C:23](O)=[O:24])[CH3:18].Cl.CN(C)CCCN=C=NCC.ON1C2C=CC=CC=2N=N1.Cl>CN(C)C=O.O.C(N(CC)CC)C>[CH2:17]([O:19][C:20](=[O:26])[CH:21]=[CH:22][C:23](=[O:24])[NH:2][CH2:3][C:4]1[CH:13]=[C:12]([Br:14])[CH:11]=[C:10]2[C:5]=1[NH:6][C:7](=[O:16])[C:8](=[O:15])[NH:9]2)[CH3:18]

참가 물질

9

반응물 5

HCID 313Hydrochloric AcidHCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 5358902Monoethyl fumarateHCID 18706500HCID 18706500, 화합물

생성물 1

HCID 54239092HCID 54239092, 화합물

시약·촉매·용매 3

HCID 962Water용매HCID 6228Dimethylformamide용매HCID 8471Triethylamine용매

실험 절차

351 mg (1 mmol) of 5-aminomethyl-7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline hydrochloride, (Example 2) 217 mg (1.5 equiv.) of fumaric acid monoethyl ester, 0.210 ml of triethylamine, 383 mg (2 equiv.) of N-(3-dimethylaminopropyl)-N'-ethyl-carbodiimide hydrochloride and 270 mg (2 equiv.) of 1-hydroxy-benzotriazole are stirred at 20° C. in dried dimethylformamide for 18 hours. The mixture is poured into 700 ml of water and 3 ml of 1 N hydrochloric acid and stirred for 15 minutes. The solid is filtered off, washed with water and dried.

후처리

  1. filtrationThe solid is filtered off
  2. washwashed with water
  3. customdried

출처 및 근거

ORD 기록
ord-9c3287a3d9f44c2989b7becbb0df39e3
출처 데이터셋
uspto-grants-2000_06
특허 번호
US06080743

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