Carbon tetrabromide → HCID 53770216, 화합물

HRID 1422344노트

반응식

HRID 1422344 반응식
C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[C:20]([Br:24])(Br)(Br)Br.[Cl:25][C:26]1[CH:27]=[C:28]([C:33]2[CH:40]=[CH:39][C:36](CO)=[CH:35][CH:34]=2)[CH:29]=[C:30]([Cl:32])[CH:31]=1>C(OCC)C.C(Cl)Cl>[Cl:25][C:26]1[CH:27]=[C:28]([C:33]2[CH:40]=[CH:39][C:36]([CH2:20][Br:24])=[CH:35][CH:34]=2)[CH:29]=[C:30]([Cl:32])[CH:31]=1

참가 물질

6

반응물 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 11288229(3',5'-Dichloro[1,1'-biphenyl]-4-yl)methanol

생성물 1

HCID 53770216HCID 53770216, 화합물

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6344Dichloromethane용매

실험 절차

To a solution of triphenylphospine (636 mg, 2.42 mmol) and carbon tetrabromide (830 mg, 2.50 mmol) in diethyl ether (5 mL) was added a solution of 4-(3',5'-bis-chlorophenyl) benzyl alcohol (50 mg, 1.98 mmol) in CH2Cl2 (12 mL). The reaction was stirred at ambient temperature for 16 hours, silica gel was than added and the solvent evaporated in vacuo. The product was isolated by chromatography (Silica gel, 10-30% EtOAc in hexanes) and obtained as a white solid.

후처리

  1. additionthan added
  2. customthe solvent evaporated in vacuo
  3. customThe product was isolated by chromatography (Silica gel, 10-30% EtOAc in hexanes)
  4. customobtained as a white solid

출처 및 근거

ORD 기록
ord-bad8f4f388c7478aa18d0c8d52b766e7
출처 데이터셋
uspto-grants-2000_06
특허 번호
US06080870

반응 노트

불러오는 중…