Hydrochloric Acid → HCID 71093738, 화합물

HRID 1424531노트

반응식

HRID 1424531 반응식
C[O:2][C:3]([C:5]1(OC)[O:9][N:8]=[C:7]([C:10]2[CH:15]=[CH:14][C:13]([C:16]#[N:17])=[CH:12][C:11]=2[F:18])[CH2:6]1)=[O:4].[OH-].[Na+].Cl>O1CCCC1>[C:16]([C:13]1[CH:14]=[CH:15][C:10]([C:7]2[CH:6]=[C:5]([C:3]([OH:4])=[O:2])[O:9][N:8]=2)=[C:11]([F:18])[CH:12]=1)#[N:17]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 866861563-(4-Cyano-2-fluoro-phenyl)-5-methoxy-4,5-dihydro-isoxazole-5-carboxylic acid methyl ester

생성물 1

HCID 71093738HCID 71093738, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 3-(4-cyano-2-fluoro-phenyl)-5-methoxy-4,5-dihydro-isoxazole-5-carboxylic acid methyl ester (172 mg), 1N aqueous NaOH solution (2 mL), and tetrahydrofuran (5 mL) is stirred at room temperature for 3 h. The reaction mixture is acidified with 1 N hydrochloric acid (approximately pH 3) and concentrated in vacuo.

후처리

  1. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-8d11dba13ce248d2bd3d9f4ac70e1e84
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08927726B2

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