7-Bromo-1-Chloroisoquinoline → 7-bromo-2-(N-propylamino)isoquinoline
반응식
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[C:9]2Cl)=[CH:4][CH:3]=1>C(N)CC>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]([NH:8][CH2:7][CH2:6][CH3:5])[CH2:9]2)=[CH:4][CH:3]=1참가 물질
3
실험 절차
A solution of 7-bromo-1-chloroisoquinoline in propylamine (15.0 mL) was heated at 70° C. in a sealed tube overnight. The reaction mixture was concentrated under reduced pressure, then dissolved in chloroform and washed with saturated sodium bicarbonate, saturated sodium chloride, dried (sodium sulfate), filtered, and concentrated under reduced pressure to yield 7-bromo-2-(N-propylamino)isoquinoline (820 mg): ESI MS m/z 266 [M+H]+.
후처리
- concentrationThe reaction mixture was concentrated under reduced pressure
- dissolutiondissolved in chloroform
- washwashed with saturated sodium bicarbonate, saturated sodium chloride
- dry with materialdried (sodium sulfate)
- filtrationfiltered
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-d4e7541abda242baa613fc8098349853
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07727997B2
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