Triethylamine → HCID 53404370, 화합물

HRID 1426361노트

반응식

HRID 1426361 반응식
F[C:2](F)(F)[C:3]([O:5][C:6](=O)[C:7]([F:10])([F:9])[F:8])=[O:4].[CH3:14][C:15](C)=[CH:16]C(Cl)=O.C(N(CC)CC)C>C(Cl)(Cl)Cl>[CH3:14][C:15]1[CH:16]=[C:6]([C:7]([F:10])([F:9])[F:8])[O:5][C:3](=[O:4])[CH:2]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 9845Trifluoroacetic anhydrideHCID 1023943-Methyl-2-butenoyl chloride

생성물 1

HCID 53404370HCID 53404370, 화합물

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a solution of trifluoroacetic anhydride (10.63 g, 50.61 mmol) and 3,3-dimethylacryloyl chloride (5.0 g, 42 mmol) in chloroform (85 mL) at 0° C. was added triethylamine (12.91 mL, 92.60 mmol). The resulting reaction mixture was stirred at same temperature for 1 h, then allowed to warm to room temperature overnight. The reaction solution was washed with water (2×), saturated sodium bicarbonate, water, and brine, and then dried over Na2SO4, filtered and concentrated. The crude residue was used in next step.

후처리

  1. customThe resulting reaction mixture
  2. washThe reaction solution was washed with water (2×), saturated sodium bicarbonate, water, and brine
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-26faaa2f34564c4787b40085e37b2b05
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08933085B2

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