Acetic Acid → HCID 86688152, 화합물

HRID 1428947노트

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HRID 1428947 반응식
[OH-].[Na+].[CH2:3]([N:5]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[C:12]([CH3:17])[CH:11]=2)[N:7]=[C:6]1CC#N)[CH3:4].[C:21]([OH:24])(=[O:23])[CH3:22]>O.CS(C)=O>[CH2:3]([N:5]1[CH:9]=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[C:12]([CH3:17])[CH:11]=2)[N:7]=[C:6]1[CH2:22][C:21]([OH:24])=[O:23])[CH3:4]

참가 물질

6

반응물 3

HCID 176Acetic AcidHCID 14798Sodium HydroxideHCID 86688150HCID 86688150, 화합물

생성물 1

HCID 86688152HCID 86688152, 화합물

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 962Water용매2회

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온도
100 °C

실험 절차

930 mg sodium hydroxide in 6 mL water was added to 525 mg (1-ethyl-4-(4-fluoro-3-methyl-phenyl)-1H-imidazol-2-yl)-acetonitrile in 2 mL DMSO. The reaction was stirred 4 h at 100° C. The mixture was diluted with water acidified with concentrated acetic acid and extracted with ethylacetate. The organic layer was dried and evaporated. The residue was crystallized with diethyl ether to give 60 mg of the desired product. Rt: 0.94 min (method K), (M+H)+: 263

후처리

  1. extractionextracted with ethylacetate
  2. customThe organic layer was dried
  3. customevaporated
  4. customThe residue was crystallized with diethyl ether

출처 및 근거

ORD 기록
ord-021db7d8c19245cfb368aeb748acb1f2
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08937176B2

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