Methyl iodide → HCID 178503559, 화합물

HRID 1429184

반응식

HRID 1429184 반응식
[CH3:1]I.[NH:3]1[C:10](=[O:11])[CH2:9][C:7](=[O:8])[NH:6][C:4]1=[S:5]>CCO.[OH-].[Na+].O>[CH3:1][S:5][C:4]1[N:6]=[C:7]([OH:8])[CH:9]=[C:10]([OH:11])[N:3]=1

참가 물질

6

반응물 2

HCID 6328Methyl iodideHCID 2723628Thiobarbituric acid

생성물 1

HCID 178503559HCID 178503559, 화합물

시약·촉매·용매 3

HCID 702Ethanol용매HCID 962Water용매HCID 14798Sodium Hydroxide용매

실험 절차

Methyl iodide (32.64 g, 220 mmol) was added dropwise to a suspension of thiobarbituric acid (29 g, 200 mmol) in EtOH (300 ml) and 2M NaOH solution in water (110 ml) at room temperature. The mixture was stirred at room temperature overnight and then stirred for two hours at 60° C. The ethanol was removed, water was added and the mixture was allowed to stay for 2 hours on an ice bath. The solid title compound was filtered of, washed with ice cold water and dried (30 g, 95%).

후처리

  1. stirringstirred for two hours at 60° C
  2. customThe ethanol was removed
  3. additionwater was added
  4. waitto stay for 2 hours on an ice bath
  5. filtrationThe solid title compound was filtered of,
  6. washwashed with ice cold water
  7. customdried (30 g, 95%)

출처 및 근거

ORD 기록
ord-70a84a861a8c4482820164954375ee84
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08937080B2

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