Methyl iodide → 1-Trityl-4-methoxymethylpyrazole

HRID 1429293

반응식

HRID 1429293 반응식
[C:1]([N:20]1[CH:24]=[C:23]([CH2:25][OH:26])[CH:22]=[N:21]1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Na+].I[CH3:30]>O1CCCC1>[C:1]([N:20]1[CH:24]=[C:23]([CH2:25][O:26][CH3:30])[CH:22]=[N:21]1)([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 10688521(1-Trityl-1H-pyrazol-4-yl)methanol

생성물 1

HCID 685309021-Trityl-4-methoxymethylpyrazole수율 93%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

This compound is obtained by reacting 1-trityl-4-hydroxymethylpyrazole (555 mg; 1.63 mmol) in dry tetrahydrofuran with sodium hydride (98 mg; 2.44 mmol) and iodomethane (0.5 mL; 8.15 mmol). Yield: 93% (536 mg, 1.51 mmol).

후처리

  1. customThis compound is obtained

출처 및 근거

ORD 기록
ord-6641dc0a1dd34e46b0fd2afdbabbbfbe
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08940273B2

연결된 노트

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