1H-Indazole, 1-methyl-6-nitro- → 1-methyl-1H-indazol-6-amine

HRID 1429445

반응식

HRID 1429445 반응식
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([N+:11]([O-])=O)[CH:9]=2)[CH:4]=[N:3]1.OCC1(OC[C@@H](O)[C@@H](O)[C@H]1O)O>CCO.C1COCC1.O=[Pt]=O>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([NH2:11])[CH:9]=2)[CH:4]=[N:3]1

참가 물질

6

반응물 2

HCID 812901H-Indazole, 1-methyl-6-nitro-HCID 441036D-Psicose

생성물 1

HCID 8404331-methyl-1H-indazol-6-amine수율 90%

시약·촉매·용매 3

HCID 345198Adams' catalyst촉매HCID 702Ethanol용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 1-methyl-6-nitro-1H-indazole (1.2 g, 0.7 mmol) in EtOH (50 ml) and THF (15 ml) was added PtO2 (125 mg) at 26° C. The mixture was stirred for 1.5 h at 26° C. under a H2 atmosphere at 30 Psi. Once the reaction was complete by TLC analysis, the mixture was filtered and the filtrate concentrated to give the target crude product as a white solid which was used in the next step without further purification (1.0 g, Yield 90%). LCMS (m/z): 148.1 (M+1).

후처리

  1. filtrationthe mixture was filtered
  2. concentrationthe filtrate concentrated
  3. customto give the target crude product as a white solid which
  4. customwas used in the next step without further purification (1.0 g, Yield 90%)

출처 및 근거

ORD 기록
ord-b30f9ff4a6764800a887e9a8139343a2
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08940726B2

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