Hydrochloric Acid → 3-Methyl-1,2-thiazole-4-carboxylic acid
반응식
[CH3:1][C:2]1[C:6]([C:7]([O-:9])=[O:8])=[CH:5][S:4][N:3]=1.[OH-].[Na+].Cl>C1COCC1.CO.O>[CH3:1][C:2]1[C:6]([C:7]([OH:9])=[O:8])=[CH:5][S:4][N:3]=1참가 물질
5
반응 조건
- 온도
- 40 °C
실험 절차
To a solution of 3-methylisothiazole-4-carboxylate (C-3) (4.73 g, 30.1 mmol) in THF-MeOH—H2O (2:1:1, 50 mL), NaOH (3.61 g, 90.3 mmol) is added and the resulting mixture is stirred at 40° C. for 16 h. The mixture is allowed to cool to RT and then acidified with concentrated HCl to adjust the pH to 2-3. The precipitate is collected by filtration, rinsed with water and dried in vacuo to afford the product, 3-methylisothiazole-4-carboxylic acid (C-4).
후처리
- temperatureto cool to RT
- filtrationThe precipitate is collected by filtration
- washrinsed with water
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-901e52364966450d962c46576a3af18a
- 출처 데이터셋
- uspto-grants-2015_01
- 특허 번호
- US08940742B2
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