Hydrochloric Acid → (S)-3-hex-5-enylsulfanyl-2-methyl-propionic acid

HRID 1432101노트

반응식

HRID 1432101 반응식
[C:1]([S:4][CH2:5][C@@H:6]([CH3:10])[C:7]([OH:9])=[O:8])(=O)[CH3:2].[OH-].[Na+].Br[CH2:14][CH2:15][CH2:16][CH2:17]C=C.Cl>CO.CCOC(C)=O>[CH2:1]([S:4][CH2:5][C@@H:6]([CH3:10])[C:7]([OH:9])=[O:8])[CH2:2][CH2:17][CH2:16][CH:15]=[CH2:14]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 759066-Bromo-1-hexeneHCID 2724506D-beta-acetylthioisobutyric acid

생성물 1

HCID 86611584(S)-3-hex-5-enylsulfanyl-2-methyl-propionic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 8857Ethyl Acetate용매

실험 절차

A solution of 1.62 g (10 mmol) (S)-3-acetylsulfanyl-2-methyl-propionic acid in 20 ml MeOH is treated with 7.5 ml 4N NaOH and 1.63 g (10 mmol) 6-bromo-hex-1-ene. After being stirred for 1 h at rt the mixture is diluted with 50 ml EtOAc and acidified with 25 ml 1N HCl. The organic phase is washed with brine, dried with sodium sulfate and concentrated in vacuo to yield (S)-3-hex-5-enylsulfanyl-2-methyl-propionic acid as an oil which is used without purification for the next step.

후처리

  1. washThe organic phase is washed with brine
  2. dry with materialdried with sodium sulfate
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-5d0a35cfe797481585345ba553764e3f
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07612055B2

반응 노트

불러오는 중…