Succinic anhydride → HCID 57512111, 화합물

HRID 14329

반응식

HRID 14329 반응식
[NH2:1][CH:2]([CH2:18][C:19]1[CH:24]=[C:23]([F:25])[CH:22]=[C:21]([F:26])[CH:20]=1)[CH:3]([OH:17])[CH2:4][NH:5][C:6]1([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][CH3:16])[CH:10]=2)[CH2:8][CH2:7]1.[C:27]1(=[O:33])[O:32][C:30](=[O:31])[CH2:29][CH2:28]1>C(Cl)(Cl)Cl>[F:26][C:21]1[CH:20]=[C:19]([CH:24]=[C:23]([F:25])[CH:22]=1)[CH2:18][C@H:2]([NH:1][C:27](=[O:33])[CH2:28][CH2:29][C:30]([OH:32])=[O:31])[C@H:3]([OH:17])[CH2:4][NH:5][C:6]1([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][CH3:16])[CH:10]=2)[CH2:8][CH2:7]1

참가 물질

4

반응물 2

HCID 7922Succinic anhydrideHCID 210854823-Amino-4-(3,5-difluoro-phenyl)-1-[1-(3-ethyl-phenyl)-cyclopropylamino]-butan-2-ol

생성물 1

HCID 57512111HCID 57512111, 화합물

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a solution of 3-Amino-4-(3,5-difluoro-phenyl)-1-[1-(3-ethyl-phenyl)-cyclopropylamino]-butan-2-ol (0.500 g, 1.387 mmol) in chloroform (7 ml) was added TEA (0.58 ml, 4.161 mmol) with stirring under nitrogen for 30 min. To this solution was added succinic anhydride (0.138 g, 1.387 mmol) and reaction was stirred overnight at 50° C. The next morning reaction mixture was concentrated in vacuo, yielding the product. (ES+: 461.2)

후처리

  1. additionTo this solution was added
  2. stirringwas stirred overnight at 50° C
  3. customThe next morning reaction mixture
  4. concentrationwas concentrated in vacuo
  5. customyielding the product

출처 및 근거

ORD 기록
ord-4a032367bbd647bf9b5da8cedcc1a131
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727997B2

연결된 노트

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