Carbon tetrabromide → HCID 60209911, 화합물

HRID 1433100노트

반응식

HRID 1433100 반응식
O[CH2:2][C:3]1[CH:4]=[N:5][C:6]([S:9][CH3:10])=[N:7][CH:8]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:31]>C1C=CC=CC=1>[Br:31][CH2:2][C:3]1[CH:4]=[N:5][C:6]([S:9][CH3:10])=[N:7][CH:8]=1

참가 물질

5

반응물 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 22050485(2-(Methylsulfanyl)pyrimidin-5-yl)methanol

생성물 1

HCID 60209911HCID 60209911, 화합물수율 61%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

5-hydroxymethyl-2-methylthiopyrimidine (0.1 g, 0.61 mmol), triphenylphosphine (0.45 g, 1.7 mmol) and carbon tetrabromide (0.28 g, 0.85 mmol) are stirred in benzene (5 mL) for 24 h. The mixture is evaporated and the residue is purified by flash chromatography (silica gel, 4:1 hexanes/ethyl acetate) to provide the intermediate title compound as a white solid (0.08 g, 61%). MS (ES), 219/221 [M+H]+ (Br).

후처리

  1. customThe mixture is evaporated
  2. customthe residue is purified by flash chromatography (silica gel, 4:1 hexanes/ethyl acetate)

출처 및 근거

ORD 기록
ord-e5c24fd45b004b6bb157294d4c716446
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07612075B2

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