4-[2-(6-Benzyloxy-3-methyl-1H-indol-5-yl)-2-oxo-ethyl]-piperazine-1-carboxylic acid benzyl ester → 4-[1-(6-Benzyloxy-3-methyl-1H-indole-5-carbonyl)-2-dimethylamino-vinyl]-piperazine-1-carboxylic acid benzyl ester

HRID 1433163

반응식

HRID 1433163 반응식
[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][N:14]([CH2:17][C:18]([C:20]2[CH:21]=[C:22]3[C:26](=[CH:27][C:28]=2[O:29][CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[NH:25][CH:24]=[C:23]3[CH3:37])=[O:19])[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CN(C(OC)OC)C>[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:17]([C:18]([C:20]2[CH:21]=[C:22]3[C:26](=[CH:27][C:28]=2[O:29][CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[NH:25][CH:24]=[C:23]3[CH3:37])=[O:19])=[CH:9][N:11]([CH3:16])[CH3:12])[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

3

반응물 1

HCID 579348164-[2-(6-Benzyloxy-3-methyl-1H-indol-5-yl)-2-oxo-ethyl]-piperazine-1-carboxylic acid benzyl ester

생성물 1

HCID 690605914-[1-(6-Benzyloxy-3-methyl-1H-indole-5-carbonyl)-2-dimethylamino-vinyl]-piperazine-1-carboxylic acid benzyl ester수율 43%

시약·촉매·용매 1

HCID 78373Dimethylformamide dimethyl acetal용매

실험 절차

A solution of 4-[2-(6-benzyloxy-3-methyl-1H-indol-5-yl)-2-oxo-ethyl]-piperazine-1-carboxylic acid benzyl ester (0.661 g, 1.33 mmol) in DMFDMA (5 ml) was heated at 100° C. overnight. The solvent was removed in vacuo and the crude product purified by column chromatography in hexane/EtOAc (1:1) to afford the product (0.158 g, 22%). LC/MS: RT=5.33 min. 553 (MH+).

후처리

  1. customThe solvent was removed in vacuo
  2. customthe crude product purified by column chromatography in hexane/EtOAc (1:1)

출처 및 근거

ORD 기록
ord-c1e19cc227ec484eaef68e791d199131
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07612201B2

연결된 노트

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