Hydrochloric Acid → 2-[Methyl(methylsulfonyl)amino]-1,3-oxazole-4-carboxylic acid

HRID 14337노트

반응식

HRID 14337 반응식
[CH3:1][N:2]([S:13]([CH3:16])(=[O:15])=[O:14])[C:3]1[O:4][CH:5]=[C:6]([C:8]([O:10]CC)=[O:9])[N:7]=1.[OH-].[Li+].O1CCCC1.Cl>O>[CH3:1][N:2]([S:13]([CH3:16])(=[O:15])=[O:14])[C:3]1[O:4][CH:5]=[C:6]([C:8]([OH:10])=[O:9])[N:7]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 21086092Ethyl 2-[methyl(methylsulfonyl)amino]-1,3-oxazole-4-carboxylate

생성물 1

HCID 210854712-[Methyl(methylsulfonyl)amino]-1,3-oxazole-4-carboxylic acid수율 82.4%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a 50 ml round bottom flask was added (61 mg, 0.2457 mmoles) ethyl 2-[methyl(methylsulfonyl)amino]-1,3-oxazole-4-carboxylate, (51.5 mg, 1.2274 mmoles, 5.0 eq.) lithium hydroxide, (2.5 ml) tetrahydrofuran and (1.5 ml) water. The reaction was agitated at ambient temperature for ˜2 hours. The reaction was complete by electrospray mass spec. The reaction was worked up by adding (5 ml) 1N HCl and then extracting with ethyl acetate. The organic layer was washed with water and brine and then dried with magnesium sulfate. The solution was then evaporated to dryness, leaving (44.6 mg) of 2-[methyl(methylsulfonyl)amino]-1,3-oxazole-4-carboxylic acid.

후처리

  1. extractionextracting with ethyl acetate
  2. washThe organic layer was washed with water and brine
  3. dry with materialdried with magnesium sulfate
  4. customThe solution was then evaporated to dryness

출처 및 근거

ORD 기록
ord-eb200b5b9a7246ccbd53a3d7b0c0fb9a
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727997B2

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