3-(Boc-amino)piperidine → Hydrochloric Acid

HRID 1436034

반응식

HRID 1436034 반응식
[Cl:1][C:2]1[C:11]2[C:10]([S:12](Cl)(=[O:14])=[O:13])=[CH:9][CH:8]=[CH:7][C:6]=2[CH:5]=[N:4][CH:3]=1.[C:16]([O:20][C:21]([NH:23][CH:24]1[CH2:29][CH2:28][CH2:27][NH:26][CH2:25]1)=[O:22])([CH3:19])([CH3:18])[CH3:17]>>[C:16]([O:20][C:21]([NH:23][CH:24]1[CH2:29][CH2:28][CH2:27][N:26]([S:12]([C:10]2[C:11]3[C:2]([Cl:1])=[CH:3][N:4]=[CH:5][C:6]=3[CH:7]=[CH:8][CH:9]=2)(=[O:14])=[O:13])[CH2:25]1)=[O:22])([CH3:19])([CH3:17])[CH3:18].[NH2:23][CH:24]1[CH2:29][CH2:28][CH2:27][N:26]([S:12]([C:10]2[C:11]3[C:2]([Cl:1])=[CH:3][N:4]=[CH:5][C:6]=3[CH:7]=[CH:8][CH:9]=2)(=[O:14])=[O:13])[CH2:25]1.[ClH:1]

참가 물질

5

반응물 2

HCID 42330413-(Boc-amino)piperidineHCID 221219084-Chloroisoquinoline-5-sulfonyl chloride

생성물 3

HCID 313Hydrochloric Acid수율 1,932.7%HCID 672426693-(Tert-butoxycarbonylamino)-1-(4-chloro-5-isoquinolinesulfonyl)piperidineHCID 67242690(r/s)-3-Amino-1-(4-chloro-5-isoquinolinesulfonyl)piperidine

실험 절차

(R/S)-3-(tert-Butoxycarbonylamino)-1-(4-chloro-5-isoquinolinesulfonyl)-piperidine (Intermediate 18) is prepared from 4-chloro-5-isoquinolinesulfonyl chloride (183 mg) and 3-(tert-butoxycarbonylamino)piperidine (168 mg) according to the method described in Example 1, Step A, and then used in the method of Example 1, Step B in a similar manner to obtain the title compound as hydrochloride (164 mg (predictive yield)).

출처 및 근거

ORD 기록
ord-126c299982984ca3a1f4790663298875
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07618984B2

연결된 노트

불러오는 중…