Water → 4-(2-Amino-1,3-thiazol-4-yl)benzonitrile
반응식
[NH2:1][C:2]([NH2:4])=[S:3].[C:5]([C:7]1[CH:16]=[CH:15][C:10]([C:11](=O)[CH2:12]Br)=[CH:9][CH:8]=1)#[N:6].[OH-].[Na+].O>C(O)C>[NH2:1][C:2]1[S:3][CH:12]=[C:11]([C:10]2[CH:15]=[CH:16][C:7]([C:5]#[N:6])=[CH:8][CH:9]=2)[N:4]=1참가 물질
6
실험 절차
Thiourea (0.76 g, 10 mmol) was added to 4-cyanophenacyl bromide (2.0 g, 8.9 mmol) in ethanol (20 mL), and the reaction heated under reflux. After 45 min, the mixture was cooled to room temperature, and poured into 2N NaOH (10 mL)/water (40 mL). The precipitate was collected and air-dried to give 4-(2-amino-thiazol-4-yl)benzonitrile (1.6 g, 90%), which was used without further characterization.
후처리
- temperaturethe reaction heated
- temperatureunder reflux
- customThe precipitate was collected
- customair-dried
출처 및 근거
- ORD 기록
- ord-f829c169ee5646be8d2dcd12e1074985
- 출처 데이터셋
- uspto-grants-2009_11
- 특허 번호
- US07618990B2
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