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Hydrochloric Acid → (S)-2-sec-Butylamino-6-(cyclopropanesulfonyl-methylamino)-isonicotinic acid

HRID 1436531
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HRID 1436531 반응식
C[O:2][C:3](=[O:23])[C:4]1[CH:9]=[C:8]([N:10]([S:12]([CH:15]2[CH2:17][CH2:16]2)(=[O:14])=[O:13])[CH3:11])[N:7]=[C:6]([NH:18][C@H:19]([CH2:21][CH3:22])[CH3:20])[CH:5]=1.[OH-].[Na+].Cl>CO>[C@@H:19]([NH:18][C:6]1[CH:5]=[C:4]([CH:9]=[C:8]([N:10]([S:12]([CH:15]2[CH2:16][CH2:17]2)(=[O:13])=[O:14])[CH3:11])[N:7]=1)[C:3]([OH:23])=[O:2])([CH2:21][CH3:22])[CH3:20]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68815532(S)-2-sec-Butylamino-6-(cyclopropanesulfonyl-methylamino)-isonicotinic acid methyl ester

생성물 1

HCID 68816222(S)-2-sec-Butylamino-6-(cyclopropanesulfonyl-methylamino)-isonicotinic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Dissolve (S)-2-sec-butylamino-6-(cyclopropanesulfonyl-methylamino)-isonicotinic acid methyl ester (600 mg, 1.97 mmol) in methanol (18 mL). Slowly add 2 N NaOH (3 mL) and stir overnight at room temperature. Acidify the mixture to about pH=6 with 5 N HCl and concentrate. Dilute with ethyl acetate (30 mL) and wash the organic layer with saturated aqueous sodium chloride solution, dry (magnesium sulfate) and concentrate to give the title compound.

후처리

  1. concentrationconcentrate
  2. additionDilute with ethyl acetate (30 mL)
  3. washwash the organic layer with saturated aqueous sodium chloride solution
  4. dry with materialdry (magnesium sulfate)
  5. concentrationconcentrate

출처 및 근거

ORD 기록
ord-4ec07f6656644a06b6ca764ee73f6398
출처 데이터셋
uspto-grants-2009_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07618978B2

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