Hydrochloric Acid → HCID 68814989, 화합물

HRID 1436608노트

반응식

HRID 1436608 반응식
C[O:2][C:3](=[O:21])[C:4]1[CH:9]=[C:8]([N:10]([CH3:14])[CH2:11][CH2:12][CH3:13])[N:7]=[C:6]([N:15]([S:17]([CH3:20])(=[O:19])=[O:18])[CH3:16])[CH:5]=1.[OH-].[Li+].Cl>C1COCC1>[CH3:20][S:17]([N:15]([CH3:16])[C:6]1[CH:5]=[C:4]([CH:9]=[C:8]([N:10]([CH3:14])[CH2:11][CH2:12][CH3:13])[N:7]=1)[C:3]([OH:21])=[O:2])(=[O:18])=[O:19]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 68815178HCID 68815178, 화합물

생성물 1

HCID 68814989HCID 68814989, 화합물수율 85.6%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Dissolve 2-(methanesulfonyl-methylamino)-6-(methylpropylamino)-isonicotinic acid methyl ester (796 mg, 2.52 mmoles) in THF (35 mL) and add 1 N lithium hydroxide (12.6 mL). Stir at room temperature for 16 h, acidify with 5 N HCl (2.6 mL), and partition between diethyl ether and water. Wash the diethyl ether layer with saturated aqueous sodium chloride, dry (magnesium sulfate) and concentrate to give the title compound as a yellow solid (650 mg, 85%).

후처리

  1. custompartition between diethyl ether and water
  2. washWash the diethyl ether layer with saturated aqueous sodium chloride
  3. dry with materialdry (magnesium sulfate)
  4. concentrationconcentrate

출처 및 근거

ORD 기록
ord-ef7f5926b5b54e2e8ca6b4c69826ad85
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07618978B2

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