Sodium Hydroxide → 4-Bromoquinoline-6-carbonitrile

HRID 1437388노트

반응식

HRID 1437388 반응식
O=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]#[N:13])[CH:10]=2)[NH:5][CH:4]=[CH:3]1.P(Br)(Br)[Br:15].[OH-].[Na+]>CN(C=O)C>[Br:15][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]#[N:13])[CH:10]=2)[N:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 24614Phosphorus tribromideHCID 116583514-Hydroxyquinoline-6-carbonitrile

생성물 1

HCID 115214964-Bromoquinoline-6-carbonitrile수율 87%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of quinolinone (b) (12.0 g, 70.5 mmol) in DMF (60 ml) was treated dropwise with phosphorus tribromide (8.0 ml, 84.6 mmol) over 10 minutes (exothermic). After allowing to stir and cool to room temperature, ice water (100 ml) was added and the mixture was stirred 30 minutes, then basified to pH8 by dropwise addition of 50% NaOH with cooling. The resultant solid was filterd off, washed with water and air dried to afford a tan solid (14.3 g, 87%).

후처리

  1. stirringthe mixture was stirred 30 minutes
  2. temperaturewith cooling
  3. washwashed with water and air
  4. customdried

출처 및 근거

ORD 기록
ord-c390ae1c8dd440979a455252a9a7da2b
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07622481B2

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