Hydrochloric Acid → 2-(Methylamino)-3-nitrobenzoic acid
반응식
C[O:2][C:3](=[O:21])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[C:5]=1[N:13](C)[C:14](=O)C(F)(F)F.[OH-].[Na+].Cl>C1COCC1>[CH3:14][NH:13][C:5]1[C:6]([N+:10]([O-:12])=[O:11])=[CH:7][CH:8]=[CH:9][C:4]=1[C:3]([OH:21])=[O:2]참가 물질
5
반응 조건
- 온도
- 50 °C
실험 절차
A mixture of 2-[methyl-(2,2,2-trifluoro-acetyl)-amino]-3-nitro-benzoic acid methyl ester (1.7 g, 5.5 mmol) and 5 M aqueous NaOH (5 mL) in THF (10 mL) was stirred at 50° C. for several hours. The mixture was acidified with 4 M HCl and extracted with EtOAc to provide 2-methylamino-3-nitro-benzoic acid. MS m/z: 197.0 (M+H)+.
후처리
- extractionextracted with EtOAc
출처 및 근거
- ORD 기록
- ord-ac394f68a5854946888c22d01b7fa0c3
- 출처 데이터셋
- uspto-grants-2009_11
- 특허 번호
- US07622583B2
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