Diethyl Ether → 1,1-Diphenyl-3-bromopropan-2-ol

HRID 1438817노트

반응식

HRID 1438817 반응식
[BH4-].[Na+].[C:3]1([CH:9]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:10](=[O:13])[CH2:11][Br:12])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.CCOCC>[OH-].[Na+].CO>[C:3]1([CH:9]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:10]([OH:13])[CH2:11][Br:12])[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

참가 물질

6

반응물 3

HCID 3283Diethyl EtherHCID 27946353-Bromo-1,1-diphenylacetoneHCID 4311764Sodium borohydride

생성물 1

HCID 125490671,1-Diphenyl-3-bromopropan-2-ol수율 86%

시약·촉매·용매 2

HCID 887Methanol용매HCID 14798Sodium Hydroxide용매

실험 절차

Sodium borohydride (1 52g) in sodium hydroxide solution (15 ml 0.02M) was added to 1,1-diphenyl-3-bromo-propan-2-one (12g) in methanol (50 ml) and the solution was stirred for one hour. Isolation through ether in the usual manner afforded 1,1-diphenyl-3-bromo-propan-2-ol (10.4g 86%) as an oil.

출처 및 근거

ORD 기록
ord-3a8e4019bdc9471882738e2ad8adf007
출처 데이터셋
uspto-grants-1977_11
특허 번호
US04056630

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