Azobisisobutyronitrile → 4-Bromomethyl-2-trifluoromethylbenzonitrile

HRID 1441685노트

반응식

HRID 1441685 반응식
[CH3:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:3]=1.[Br:14]N1C(=O)CCC1=O.N(C(C)(C)C#N)=NC(C)(C)C#N>ClC(Cl)(Cl)Cl>[Br:14][CH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([C:10]([F:11])([F:12])[F:13])[CH:3]=1

참가 물질

5

반응물 3

HCID 6547AzobisisobutyronitrileHCID 67184N-bromobutanimideHCID 27755974-Methyl-2-(trifluoromethyl)benzonitrile

생성물 1

HCID 591645854-Bromomethyl-2-trifluoromethylbenzonitrile수율 157.1%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

To a refluxing mixture of 5.0 g 4-Methyl-2-(trifluoromethyl)benzonitrile in 50 ml tetrachloromethane were added a mixture of 5.77 g N-bromosuccinimide and 1.77 g 2,2′-azobis(2-methylpropionitrile). The reaction mixture was heated under reflux for three hours. The reaction mixture was filtered through a pad of celite and the solvent was removed in vacuo to obtain 11.2 g crude 4-Bromomethyl-2-trifluoromethyl-benzonitrile (impurified with the dibromo product) as a white solid. This material was used without further purification.

후처리

  1. additionwere added
  2. temperatureThe reaction mixture was heated
  3. temperatureunder reflux for three hours
  4. filtrationThe reaction mixture was filtered through a pad of celite
  5. customthe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-f1dbe9fd966e46c483507ca4ba370b6e
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07655679B2

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