Water → 2-(2,2,3,4,4,4-Hexafluorobutyl)malononitrile

HRID 1443591노트

반응식

HRID 1443591 반응식
FC(F)(F)S(O[CH2:7][C:8]([F:16])([F:15])[CH:9]([F:14])[C:10]([F:13])([F:12])[F:11])(=O)=O.C(=O)([O-])[O-].[K+].[K+].[C:25](#[N:29])[CH2:26][C:27]#[N:28].O>CS(C)=O>[F:15][C:8]([F:16])([CH:9]([F:14])[C:10]([F:13])([F:12])[F:11])[CH2:7][CH:26]([C:25]#[N:29])[C:27]#[N:28]

참가 물질

6

반응물 4

HCID 962WaterHCID 8010MalononitrileHCID 11430Potassium CarbonateHCID 588790322,2,3,4,4,4-Hexafluorobutyl trifluoromethanesulfonate

생성물 1

HCID 866125382-(2,2,3,4,4,4-Hexafluorobutyl)malononitrile수율 34.1%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매2회

실험 절차

8.0 g of 2,2,3,4,4,4-hexafluorobutyl trifluoromethanesulfonate was dissolved in 15 ml of dimethyl sulfoxide, and 6.9 g of potassium carbonate was added. 5.0 g of malononitrile dissolved in 15 ml of dimethyl sulfoxide was added dropwise thereto, and the mixture was stirred at room temperature for 3 hours. The reaction mixture was poured to water and then extracted with diethyl ether. The organic layer was washed successively with water and aqueous saturated sodium chloride, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 2.0 g of 2-(2,2,3,4,4,4-hexafluorobutyl)malononitrile.

후처리

  1. additionwas added dropwise
  2. extractionextracted with diethyl ether
  3. washThe organic layer was washed successively with water and aqueous saturated sodium chloride
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-ddbd3d1c4477408fb7b939e626d48f80
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07662402B2

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