Hydrochloric Acid → HCID 67020462, 화합물

HRID 1444097노트

반응식

HRID 1444097 반응식
[C:1]1([CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][CH:12]([C:15]([O:17]CC)=[O:16])[CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:20]>[OH-].[Na+]>[ClH:20].[C:1]1([CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][CH:12]([C:15]([OH:17])=[O:16])[CH2:11][CH2:10]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 18997131HCID 18997131, 화합물

생성물 1

HCID 67020462HCID 67020462, 화합물

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

A suspension of 1-(2-phenylethyl)-4-carbetoxypiperidine (12.2 g, 0.047 mol) obtained as described in J. Med. Chem. 1996 (39), 749-756, in 1N NaOH (100 ml) was heated under reflux for 4 h. After cooling to room temperature, the solution was made acid with 6N HCl to pH 2, concentrated by evaporation at reduced pressure, and the solid thus obtained was filtered and dried in a stove under vacuum to give the desired product (12.1 g).

후처리

  1. customobtained
  2. temperatureunder reflux for 4 h
  3. concentrationconcentrated by evaporation at reduced pressure
  4. customthe solid thus obtained
  5. filtrationwas filtered
  6. customdried in a stove under vacuum

출처 및 근거

ORD 기록
ord-74077a545b0d4b89a7b912a4c041a658
출처 데이터셋
uspto-grants-2010_02
특허 번호
US07662836B2

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