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[C:1]([O-:4])(=[O:3])[CH3:2].[NH4+:5].[CH2:6]([N:17]([CH2:29][C:30]([OH:32])=[O:31])[CH2:18][CH2:19][N:20]([CH2:25][C:26](O)=O)[CH2:21][C:22]([OH:24])=[O:23])[CH2:7][N:8]([CH2:13][C:14](O)=O)[CH2:9][C:10]([OH:12])=[O:11]>>[CH2:26]1[N:5]([CH2:2][C:1]([OH:4])=[O:3])[CH2:14][CH2:13][N:8]([CH2:9][C:10]([OH:12])=[O:11])[CH2:7][CH2:6][N:17]([CH2:29][C:30]([OH:32])=[O:31])[CH2:18][CH2:19][N:20]([CH2:21][C:22]([OH:24])=[O:23])[CH2:25]1참가 물질
3
실험 절차
Briefly, ammonium acetate, (10 μL for each mCi of 111In) is added to a reaction vial containing 111In-chloride solution. Subsequently, the DOTA-J591 solution (30 mL or 0.24 mg for each mCi of 111In) is added to the reaction vial and the mixture is gently mixed and incubated at 37° C. for 20-30 min. An aliquot of the mixture is tested to determine labeling efficiency using ITLC (SG and 5 mM DTPA, pH 5). If the binding is optimal (>70%), the reaction is stopped by the addition of 10-40 mL of 5 mM DTPA.
후처리
- additionis gently mixed and incubated at 37° C. for 20-30 min
출처 및 근거
- ORD 기록
- ord-76457df3c4b84e178d994f2abbea718f
- 출처 데이터셋
- uspto-grants-2010_02
- 특허 번호
- US07666414B2
연결된 노트
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