Formaldehyde → HCID 54232589, 화합물

HRID 1446834노트

반응식

HRID 1446834 반응식
N[C:2]1[C:7]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:16][C:17]([NH2:19])=[O:18].[CH2:20]=O.[C:22]([BH3-])#[N:23].[Na+].[OH-].[Na+]>C(#N)C.C(O)(=O)C>[C:8]([C:7]1[C:2]([N:23]([CH3:22])[CH3:20])=[C:3]([CH2:16][C:17]([NH2:19])=[O:18])[CH:4]=[CH:5][CH:6]=1)(=[O:15])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

7

반응물 4

HCID 712FormaldehydeHCID 14798Sodium HydroxideHCID 151075NepafenacHCID 5003444Sodium cyanoborohydride

생성물 1

HCID 54232589HCID 54232589, 화합물

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 6342Acetonitrile용매

실험 절차

A solution of 12.7 g (0.05 mol) of 2-amino-3-benzoyl-phenylacetamide in 150 ml of acetonitrile is treated four times with 16 ml (0.2 mole) of 37% formalin, 6.4 g (0.1 mole) of sodium cyanoborohydride and 2 ml of glacial acetic acid with a 15 minute stirring period between each treatment. The mixture is finally poured into dilute sodium hydroxide and extracted three times with diethylether. The ether extracts are combined, dried over magnesium sulfate and concentrated. The product is isolated by column chromatography.

후처리

  1. extractionextracted three times with diethylether
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated
  4. customThe product is isolated by column chromatography

출처 및 근거

ORD 기록
ord-c16df1c2c8d04b8da75839f95b0e666d
출처 데이터셋
uspto-grants-1982_02
특허 번호
US04313949

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