[H][H].P([O-])([O-])([O-])=O.Cl[C:9]1[C:14]2[N:15]=[CH:16][NH:17][C:13]=2[CH:12]=[CH:11][N:10]=1.C([O:25][C@H:26]1[C@H:30]([O:31]CC2C=CC=CC=2)[C@@H:29]([CH2:39][O:40]CC2C=CC=CC=2)[O:28][C@@H:27]1Cl)C1C=CC=CC=1.[NH2:49]N.[Na].N>[Ni]>[C@@H:27]1([N:17]2[C:13]3[CH:12]=[CH:11][N:10]=[C:9]([NH2:49])[C:14]=3[N:15]=[CH:16]2)[O:28][C@H:29]([CH2:39][OH:40])[C@@H:30]([OH:31])[C@@H:26]1[OH:25]An improved process for producing a compound of the formula ##STR7## wherein X is NH2, OH or SH; R is hydrogen or acyl containing 2 or 3 carbon atoms; and R1 is hydrogen, acyl containing 2 or 3 carbon atoms or phosphate which comprises β-D-arabinofuranosylating 4-chloro-1H-imidazo-[4,5-c]pyridine with 2,3,5-tri-O-benzyl-α-D-arabinofuranosyl chloride; treating the resulting blocked nucleoside sequentially with hydrazine, Raney nickel and sodium in liquid ammonia to obtain 1-β-D-arabinofuranosyl-1H-imidazo[4,5-c]pyridin-4-amine and acylating, phosphorylating, treating with sodium nitrate then phosphorus pentasulfide to obtain the desired compounds wherein the improvement comprises treating 4-chloro-1H-imidazo[4,5-c]pyridine with sodium hydride in a suitable solvent to form the anion having the formula ##STR8## and β-D-arabinofuranosylating said anion with 2,3,5-tri-O-benzyl-α-D-arabinofuranosyl chloride.
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