Hydrogen Bromide → HCID 20550939, 화합물

HRID 1447419노트

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HRID 1447419 반응식
[C:1]([C:4]1[S:8][CH:7]=[C:6]([C:9]([NH2:11])=[O:10])[CH:5]=1)(=[O:3])[CH3:2].[BrH:12].BrBr>C(Cl)(Cl)Cl.C(O)(=O)C>[Br:12][CH2:2][C:1]([C:4]1[S:8][CH:7]=[C:6]([C:9]([NH2:11])=[O:10])[CH:5]=1)=[O:3]

참가 물질

6

반응물 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 205509375-Acetylthiophene-3-carboxamide

생성물 1

HCID 20550939HCID 20550939, 화합물

시약·촉매·용매 2

HCID 176Acetic Acid촉매HCID 6212Chloroform용매2회

실험 절차

A solution of 5-acetylthiophene-3-carboxamide (0.5 g) in chloroform at 50° was treated with hydrogen bromide in acetic acid (4 drops) and then bromine (0.15 ml) in chloroform (10 ml) dropwise over 30 min. The resulting pale yellow solution was washed with water (2×100 ml), dried and evaporated to small volume to deposit the title compound as a white solid (0.55 g) which recrystallised from water, m.p. 150°-157° (d).

후처리

  1. washThe resulting pale yellow solution was washed with water (2×100 ml)
  2. customdried
  3. customevaporated to small volume
  4. customrecrystallised from water, m.p. 150°-157° (d)

출처 및 근거

ORD 기록
ord-e37ce2377dc84078a3014aa9c3f5b49e
출처 데이터셋
uspto-grants-1982_02
특허 번호
US04316907

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