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Hydrochloric Acid → 1-[2-(acetylthiomethyl)-5-hydroxy-6-methylheptanoyl]-L-proline

HRID 1447766
노트
인쇄 미리보기

반응식

HRID 1447766 반응식
[C:1]([S:4][CH2:5][CH:6]([CH2:17][CH2:18][C:19](=[O:23])[CH:20]([CH3:22])[CH3:21])[C:7]([N:9]1[CH2:16][CH2:15][CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8])(=[O:3])[CH3:2].[BH4-].[Na+].Cl>CO.O>[C:1]([S:4][CH2:5][CH:6]([CH2:17][CH2:18][CH:19]([OH:23])[CH:20]([CH3:21])[CH3:22])[C:7]([N:9]1[CH2:16][CH2:15][CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8])(=[O:3])[CH3:2]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 542745461-{2-[(Acetylsulfanyl)methyl]-6-methyl-5-oxoheptanoyl}-L-proline

생성물 1

HCID 543289601-[2-(acetylthiomethyl)-5-hydroxy-6-methylheptanoyl]-L-proline

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water
용매

실험 절차

1-[2-(acetylthiomethyl)-5-oxo-6-methylheptanoyl]-L-proline (1.5 g.) is dissolved in cold methanol (10 ml.) and sodium borohydride (0.12 g.) is added. After two hours the reaction mixture is diluted with water (100 ml.) acidified with concentrated hydrochloric acid and extracted with ethyl acetate. The organic layer is dried and concentrated to dryness in vacuo to give 1-[2-(acetylthiomethyl)-5-hydroxy-6-methylheptanoyl]-L-proline.

후처리

  1. extractionextracted with ethyl acetate
  2. customThe organic layer is dried
  3. concentrationconcentrated to dryness in vacuo

출처 및 근거

ORD 기록
ord-a95dbd505cfd4c2ba14a83ece9b0f8b6
출처 데이터셋
uspto-grants-1979_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04178291

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