Sulfuric Acid → Ibuprofen, (+-)-

HRID 1449227

반응식

HRID 1449227 반응식
[O-:1][C:2]([CH:4]([C:6]1[CH:15]=[CH:14][C:9]([CH2:10][CH:11]([CH3:13])[CH3:12])=[CH:8][CH:7]=1)[CH3:5])=[O:3].[Na+].S(=O)(=O)(O)O.[Cl-].[Na+]>>[OH:3][C:2]([CH:4]([C:6]1[CH:7]=[CH:8][C:9]([CH2:10][CH:11]([CH3:12])[CH3:13])=[CH:14][CH:15]=1)[CH3:5])=[O:1]

참가 물질

4

반응물 3

HCID 1118Sulfuric AcidHCID 5234Sodium ChlorideHCID 5338317Ibuprofen, Sodium Salt

생성물 1

HCID 3672Ibuprofen, (+-)-수율 93.2%

실험 절차

The aqueous basic fraction containing sodium ibuprofen salt was acidified with 6N sulfuric acid, sodium chloride was added, and then extracted twice with Skellysolve B to take up the ibuprofen acid product therein. The Skellysolve B phase was dried over sodium sulfate and evaporated to leave as residue 867.7 mg. (93.2 percent yield) of ibuprofen which was 99.9 percent pure by gas liquid chromatographic (GLC) analysis.

후처리

  1. additionwas added
  2. extractionextracted twice with Skellysolve B
  3. dry with materialThe Skellysolve B phase was dried over sodium sulfate
  4. customevaporated
  5. customto leave as residue 867.7 mg

출처 및 근거

ORD 기록
ord-9fb0f63a25da4ea98b6394c83ae0b917
출처 데이터셋
uspto-grants-1980_02
특허 번호
US04189596

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