Hydrochloric Acid → HCID 67715287, 화합물
반응식
[ClH:1].[CH2:2]([C:5]1[N:9]2[CH2:10][CH2:11][CH2:12][N:13]=[C:8]2[S:7][C:6]=1[C:14]([O:16]CC)=[O:15])[CH2:3][CH3:4].Cl>[OH-].[Na+]>[ClH:1].[CH2:2]([C:5]1[N:9]2[CH2:10][CH2:11][CH2:12][N:13]=[C:8]2[S:7][C:6]=1[C:14]([OH:16])=[O:15])[CH2:3][CH3:4]참가 물질
4
실험 절차
In 110 ml of 1N sodium hydroxide aqueous solution was suspended 9.96 g of ethyl 3-propyl-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidine-2-carboxylate hydrochloride obtained in Example 11, followed by reflux under heating for 90 minutes. After cooling, the reaction mixture was made acidic with concentrated hydrochloric acid. The precipitated crystals were collected by filtration and washed with acetone to obtain 5.3 g of the titled compound.
후처리
- temperatureby reflux
- temperatureunder heating for 90 minutes
- temperatureAfter cooling
- filtrationThe precipitated crystals were collected by filtration
- washwashed with acetone
출처 및 근거
- ORD 기록
- ord-70dc523fc299435ea2441f39d269c343
- 출처 데이터셋
- uspto-grants-1997_02
- 특허 번호
- US05599813
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