Water → Ibuprofen, Sodium Salt

HRID 1449781

반응식

HRID 1449781 반응식
[OH:1][C:2]([CH:4]([C:6]1[CH:15]=[CH:14][C:9]([CH2:10][CH:11]([CH3:13])[CH3:12])=[CH:8][CH:7]=1)[CH3:5])=[O:3].O.[OH-].[Na+:18]>C1(C)C=CC=CC=1>[Na+:18].[O-:3][C:2]([CH:4]([C:6]1[CH:7]=[CH:8][C:9]([CH2:10][CH:11]([CH3:12])[CH3:13])=[CH:14][CH:15]=1)[CH3:5])=[O:1]

참가 물질

5

반응물 3

HCID 962WaterHCID 3672Ibuprofen, (+-)-HCID 14798Sodium Hydroxide

생성물 1

HCID 5338317Ibuprofen, Sodium Salt

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
20 °C

실험 절차

A solution of (S)-enriched ibuprofen having an enantiomeric purity of 95.5% (211 kg) in toluene (797 kg) was heated to 60° C. with water (300 l) and aqueous sodium hydroxide solution (52 l--specific gravity 1.5) and allowed to settle for four hours. The aqueous layer was separated and the toluene layer washed with water. The aqueous washings and the aqueous layer were combined and residual toluene removed by distillation. Acetone (1684 kg) was added and the mixture cooled to 20° C. The sodium salt of (S)-enriched ibuprofen dihydrate (having an enantiomeric purity of 99.9%) separated, was collected by filtration and dried in vacuo. (Yield 143.5 kg).

후처리

  1. customThe aqueous layer was separated
  2. washthe toluene layer washed with water
  3. customresidual toluene removed by distillation
  4. additionAcetone (1684 kg) was added
  5. customseparated
  6. filtrationwas collected by filtration
  7. customdried in vacuo

출처 및 근거

ORD 기록
ord-89028e78ed534db184de502b0bf84df7
출처 데이터셋
uspto-grants-1997_02
특허 번호
US05599969

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