Benzyl Alcohol → (N-carbobenzyloxyaminosulfonyl)-2-(3-methylbutyl)sarcosine methyl ester

HRID 1450460노트

반응식

HRID 1450460 반응식
Cl[S:2]([N:5]=[C:6]=[O:7])(=[O:4])=[O:3].[C:8]1([CH2:14][OH:15])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.Cl.[CH3:17][O:18][C:19](=[O:28])[CH:20]([CH2:23][CH2:24][CH:25]([CH3:27])[CH3:26])[NH:21][CH3:22].C(N(CC)CC)C.Cl.[Cl-].[Na+]>C(Cl)Cl>[CH3:17][O:18][C:19](=[O:28])[CH:20]([CH2:23][CH2:24][CH:25]([CH3:26])[CH3:27])[N:21]([S:2]([NH:5][C:6]([O:15][CH2:14][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:7])(=[O:4])=[O:3])[CH3:22]

참가 물질

8

반응물 6

HCID 244Benzyl AlcoholHCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 8471TriethylamineHCID 70918Chlorosulfonyl isocyanateHCID 867494602-(3-Methylbutyl)-sarcosine methyl ester hydrochloride

생성물 1

HCID 18922249(N-carbobenzyloxyaminosulfonyl)-2-(3-methylbutyl)sarcosine methyl ester수율 87.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a stirred solution of 5.77 ml (66.78 mmol) of chlorosulfonyl isocyanate in methylene chloride was added, under nitrogen, phenylmethanol (6.89 ml, 66.57 mmol) at 0°-5° C. After stirring the above solution for 1 hour, a solution of 13.166 g (62.78 mmol) of 2-(3-methylbutyl)sarcosine methyl ester hydrochloride in methylene chloride containing triethylamine (27.33 ml, 194.62 mmol) was added at 0°-5° C., and the resulting mixture was stirred overnight allowing the mixture to warm to room temperature. The reaction mixture was poured into 600 ml of 10% aq. HCl solution, saturated with sodium chloride, and the organic layer was separated. The aqueous layer was extracted with methylene chloride and the combined organic layer was washed with brine, dried over magnesium sulfate, and concentrated in vacuo to yield 21.22 g (87.2%) of N-(carbobenzyloxyaminosulfonyl)-2-(3-methylbutyl)-sarcosine methyl ester (Formula XII: R=CH3 ; R1 =(CH2)2CH(CH3)2 ; R2 =H; R3 =CH3) which was purified by silica column chromatography (20% ethyl acetate in hexane) to afford an oil.

후처리

  1. customat 0°-5° C
  2. additionwas added at 0°-5° C.
  3. stirringthe resulting mixture was stirred overnight
  4. customthe organic layer was separated
  5. extractionThe aqueous layer was extracted with methylene chloride
  6. washthe combined organic layer was washed with brine
  7. dry with materialdried over magnesium sulfate
  8. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-0df295229239479d9774afff205fe3ef
출처 데이터셋
uspto-grants-1997_02
특허 번호
US05602154

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