Chloroacetone → 1-((4-Bromophenyl)thio)propan-2-one

HRID 1450502노트

반응식

HRID 1450502 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([SH:8])=[CH:4][CH:3]=1.[OH-].[Na+].Cl[CH2:12][C:13](=[O:15])[CH3:14]>O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:12][C:13](=[O:15])[CH3:14])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 6571ChloroacetoneHCID 14798Sodium HydroxideHCID 660494-Bromothiophenol

생성물 1

HCID 8219021-((4-Bromophenyl)thio)propan-2-one수율 104.5%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a stirred solution of 4-bromothiophenol (5.09 g, 26.9 mmol) in NaOH (1.08 g, 26.9 mmol) and water (32 ml) was added chloroacetone (2.17 ml, 27.3 mmol) and the mixture was stirred under nitrogen for 45min before extracting with ether, washing with water, drying (Na2SO4) and evaporating in vacuo, leaving 6.89 g (100%) of the title compound as a white solid, δ (CDCl3) 2.27 (3H, s), 3.65 (2H, s), 7.20 (2H, d, J=8.5 Hz), 7.41 (2H, d, J=8.5 Hz).

후처리

  1. extractionbefore extracting with ether
  2. washwashing with water
  3. dry with materialdrying (Na2SO4)
  4. customevaporating in vacuo

출처 및 근거

ORD 기록
ord-393e749c4d714c248d2930b667945919
출처 데이터셋
uspto-grants-1997_02
특허 번호
US05602163

반응 노트

불러오는 중…