Hydrochloric Acid → Phosphonic acid, (p-acetamidophenyl)-

HRID 1451058노트

반응식

HRID 1451058 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([P:8](=[O:11])([OH:10])[OH:9])=[CH:4][CH:3]=1.C(=O)(O)[O-].[Na+].[C:17](OC(=O)C)(=[O:19])[CH3:18].Cl>O>[C:17]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([P:8](=[O:10])([OH:9])[OH:11])=[CH:4][CH:3]=1)(=[O:19])[CH3:18]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 7918Acetic Anhydride2회HCID 53590P-(4-Aminophenyl)phosphonic acidHCID 516892Sodium Bicarbonate

생성물 1

HCID 155214Phosphonic acid, (p-acetamidophenyl)-수율 38.5%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a suspension of (4-aminophenyl)phosphonic acid (Aldrich, 0.00058 mol) in water (1.5 mL) was added sufficient sodium bicarbonate to make a clear solution. To the mixture, acetic anhydride (0.2 mL, 0.002 mol) was added and stirred for 0.5 h. Again, acetic anhydride (0.2 mL, 0.002 mol) was added and stirred for 0.5 h. The mixture was let stand at room temperature for 2 h and then concentrated hydrochloric acid (0.5 mL) was added. Fine white needles separated out which were collected by filtration, washed with water and dried to give 0.048 g (38.5%) of the title compound, mp 228° C. (rep. mp 229° C.--Bauer, H. J. Am. Chem. Soc. 1947, 63, 2137-2138).

후처리

  1. stirringstirred for 0.5 h
  2. customat room temperature
  3. customfor 2 h
  4. customFine white needles separated out which
  5. filtrationwere collected by filtration
  6. washwashed with water
  7. customdried

출처 및 근거

ORD 기록
ord-c569f7cd0cf84707af9a61fa029e1fb9
출처 데이터셋
uspto-grants-1997_02
특허 번호
US05602277

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