Ammonia → 4-Thiazolemethanol, alpha-(bromomethyl)-2-(trifluoromethyl)-
반응식
[F:1][C:2]([F:13])([F:12])[C:3]1[S:4][CH:5]=[C:6]([C:8](=[O:11])[CH2:9][Br:10])[N:7]=1.[BH4-].[Na+].Cl.N>CO>[F:13][C:2]([F:1])([F:12])[C:3]1[S:4][CH:5]=[C:6]([CH:8]([OH:11])[CH2:9][Br:10])[N:7]=1참가 물질
6
반응 조건
- 온도
- 10 °C
실험 절차
6 g (0.022 mol) of 2-Trifluoromethyl-4-bromoacetyl-thiazole are dissolved in 150 ml of methanol, and the solution is cooled to 10° C. and 0.63 g of sodium borohydride is added. After 15 minutes ice is added, and the mixture is acidified with hydrochloric acid, made alkaline with ammonia and extracted by shaking with methylene chloride. The organic phase is dried over sodium sulphate, filtered and concentrated. An oil is obtained and is reacted further as the crude product.
후처리
- additionAfter 15 minutes ice is added
- extractionextracted
- dry with materialThe organic phase is dried over sodium sulphate
- filtrationfiltered
- concentrationconcentrated
- customAn oil is obtained
출처 및 근거
- ORD 기록
- ord-da46e8d8a42d419fa1ec06949cf3316d
- 출처 데이터셋
- uspto-grants-1997_02
- 특허 번호
- US05604225
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