Sodium Hydroxide → 4-(3-Bromopropoxy)aniline

HRID 1451643노트

반응식

HRID 1451643 반응식
[Br:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12]C(=O)C)=[CH:8][CH:7]=1.[OH-].[Na+]>Cl>[Br:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][CH:7]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 10849771N-[4-(3-bromopropoxy)phenyl]acetamide

생성물 1

HCID 199745634-(3-Bromopropoxy)aniline

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A mixture of the product of part (i) above (13 g) and 5N hydrochloric acid (200 ml) was heated under reflux for 2 h. After cooling, the mixture was basified with sodium hydroxide solution and extracted with dichloromethane. The organic phase was evaporated to give the title compound (7 g) as an oil. IR includes a peak at 3360-3450 cm-1 (NH).

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 2 h
  3. temperatureAfter cooling
  4. extractionextracted with dichloromethane
  5. customThe organic phase was evaporated

출처 및 근거

ORD 기록
ord-844f3f95de144ec39e3629178d3a957b
출처 데이터셋
uspto-grants-1997_02
특허 번호
US05604237

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