Sodium Hydroxide → (3,4-Bis(difluoromethoxy)phenyl)methanol

HRID 1451923노트

반응식

HRID 1451923 반응식
[F:1][CH:2]([F:16])[O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[O:12][CH:13]([F:15])[F:14])[CH:7]=[O:8].[BH4-].[Na+].[OH-].[Na+]>C(O)C>[F:1][CH:2]([F:16])[O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[O:12][CH:13]([F:15])[F:14])[CH2:7][OH:8]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 4311764Sodium borohydrideHCID 145092693,4-Bis(difluoromethoxy)benzaldehyde

생성물 1

HCID 53484633(3,4-Bis(difluoromethoxy)phenyl)methanol

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

3,4-Bisdifluoromethoxybenzaldehyde (26.2 g, 110 mmol) in absolute ethanol (150 mL) was treated with sodium borohydride (8.32 g, 220 mmol) under an argon atmosphere at room temperature for 0.5 h. Ten percent aqueous sodium hydroxide (130 mL) was added, the ethanol was removed in vacuo, the mixture was partitioned between ether and water and was etracted twice with ether. The organic extract was dried (magnesium sulfate) and evaporated to a pale yellow oil (26.4 g, 100%).

후처리

  1. customthe ethanol was removed in vacuo
  2. customthe mixture was partitioned between ether and water
  3. extractionThe organic extract
  4. dry with materialwas dried (magnesium sulfate)
  5. customevaporated to a pale yellow oil (26.4 g, 100%)

출처 및 근거

ORD 기록
ord-8af9592a8fbd40bc9b0896e4e8df7e8b
출처 데이터셋
uspto-grants-1997_02
특허 번호
US05605923

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